Drug interactions
Didanosine + Mesalamine
Severity: Moderate
Didanosine and Mesalamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some oral mesalamine products release drug in a pH-dependent manner. Buffered didanosine formulations raise gastric pH and may cause premature or altered release, reducing efficacy.
What this interaction means in plain words
Didanosine and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Didanosine belongs to Anti Virals; Mesalamine belongs to Gastrointestinal Tract.
Why it happens
Increased gastric pH from buffered didanosine alters pH-dependent mesalamine release.
What to do
Give extended-release mesalamine capsules 1 hour before or 4 hours after didanosine, and monitor colitis control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mesalamine
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Mesalamine?
MediHelp rates the interaction as moderate. Didanosine and Mesalamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Some oral mesalamine products release drug in a pH-dependent manner. Buffered didanosine formulations raise gastric pH and may cause premature or altered release, reducing efficacy.
How serious is the interaction between Didanosine and Mesalamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give extended-release mesalamine capsules 1 hour before or 4 hours after didanosine, and monitor colitis control.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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