Drug interactions
Didanosine + Pexidartinib
Severity: Major
Didanosine and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a risk of serious and sometimes fatal liver injury. Didanosine can also cause hepatotoxicity, including noncirrhotic portal hypertension and hepatic steatosis, so combining them raises the chance of liver damage.
What this interaction means in plain words
Didanosine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Didanosine belongs to Anti Virals; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two drugs that can independently injure the liver.
What to do
Avoid the combination where possible and use an alternative antiretroviral. If unavoidable, monitor liver enzymes and bilirubin closely and stop pexidartinib if hepatotoxicity develops.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Didanosine with Pexidartinib?
MediHelp rates the interaction as major. Didanosine and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a risk of serious and sometimes fatal liver injury. Didanosine can also cause hepatotoxicity, including noncirrhotic portal hypertension and hepatic steatosis, so combining them raises the chance of liver damage.
How serious is the interaction between Didanosine and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use an alternative antiretroviral. If unavoidable, monitor liver enzymes and bilirubin closely and stop pexidartinib if hepatotoxicity develops.
What other medicines interact with Didanosine?
MediHelp also lists interactions of Didanosine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Hydroxycarbamide, Ribavirin. The full list is on the Didanosine page.
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