Drug interactions
Didanosine + Zidovudine
Severity: Minor
Didanosine and Zidovudine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The two nucleoside analogues are often used together and have largely additive antiviral activity, with overlapping bone marrow and neuropathic toxicities being a theoretical concern. Reported pharmacokinetic effects on didanosine exposure are small and generally not clinically meaningful.
What this interaction means in plain words
Didanosine and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Didanosine belongs to Anti Virals; Zidovudine belongs to Anti Virals.
Why it happens
Possible small reduction in renal clearance of didanosine; additive pharmacodynamic toxicity is theoretical.
What to do
No dose adjustment is usually needed; monitor blood counts and watch for peripheral neuropathy or pancreatitis during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zidovudine
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Zidovudine Contraindicated
- Stavudine + Zidovudine Contraindicated
- Atidarsagene autotemcel + Zidovudine Major
- Betibeglogene autotemcel + Zidovudine Major
- Carboplatin + Zidovudine Major
- Cisplatin + Zidovudine Major
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Didanosine with Zidovudine?
MediHelp rates the interaction as minor. Didanosine and Zidovudine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. The two nucleoside analogues are often used together and have largely additive antiviral activity, with overlapping bone marrow and neuropathic toxicities being a theoretical concern. Reported pharmacokinetic effects on didanosine exposure are small and generally not clinically meaningful.
How serious is the interaction between Didanosine and Zidovudine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; monitor blood counts and watch for peripheral neuropathy or pancreatitis during therapy.
What other medicines interact with Zidovudine?
MediHelp also lists interactions of Zidovudine with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Stavudine, Atidarsagene autotemcel. The full list is on the Zidovudine page.
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