Drug interactions
Dienogest / estradiol valerate + Dronedarone
Severity: Minor
Dienogest / estradiol valerate and Dronedarone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone may raise estradiol and dienogest concentrations because both are partly cleared by CYP3A4. This could increase estrogenic and progestogenic adverse effects such as breast tenderness, headache, nausea and breakthrough bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 reduces hormone metabolism.
What to do
No dose change is usually needed; ask about estrogenic adverse effects and review the contraceptive or hormone regimen if they become troublesome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Dronedarone?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Dronedarone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dronedarone may raise estradiol and dienogest concentrations because both are partly cleared by CYP3A4. This could increase estrogenic and progestogenic adverse effects such as breast tenderness, headache, nausea and breakthrough bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Dronedarone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; ask about estrogenic adverse effects and review the contraceptive or hormone regimen if they become troublesome.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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