Drug interactions
Dienogest / estradiol valerate + Gemifloxacin
Severity: Minor
Dienogest / estradiol valerate and Gemifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorized to reduce hormone levels through altered gut flora, but evidence for non-rifamycin antibiotics such as fluoroquinolones is lacking. Contraceptive failure is considered unlikely.
What this interaction means in plain words
Dienogest / estradiol valerate and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogen from gut flora changes; not demonstrated for fluoroquinolones.
What to do
No routine change is needed. Advise additional contraception if the patient has vomiting or severe diarrhea while on treatment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Gemifloxacin?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorized to reduce hormone levels through altered gut flora, but evidence for non-rifamycin antibiotics such as fluoroquinolones is lacking. Contraceptive failure is considered unlikely.
How serious is the interaction between Dienogest / estradiol valerate and Gemifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Advise additional contraception if the patient has vomiting or severe diarrhea while on treatment.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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