Drug interactions
Dienogest / estradiol valerate + Gentamicin
Severity: Minor
Dienogest / estradiol valerate and Gentamicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral gentamicin could in theory alter gut flora and reduce enterohepatic recycling of estrogens. Systemic gentamicin does not meaningfully affect gut flora, and clinical evidence of reduced hormone effect is lacking. The risk of contraceptive failure is considered very low.
What this interaction means in plain words
Dienogest / estradiol valerate and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in gut bacterial deconjugation of estrogens and so less enterohepatic recirculation; not established for aminoglycosides.
What to do
No routine action is needed. Counsel the patient to report breakthrough bleeding, and consider backup contraception only if prolonged oral antibiotic therapy causes vomiting or diarrhea.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dienogest / estradiol valerate and Gentamicin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Dienogest / estradiol valerate with Gentamicin?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Gentamicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral gentamicin could in theory alter gut flora and reduce enterohepatic recycling of estrogens. Systemic gentamicin does not meaningfully affect gut flora, and clinical evidence of reduced hormone effect is lacking. The risk of contraceptive failure is considered very low.
How serious is the interaction between Dienogest / estradiol valerate and Gentamicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Counsel the patient to report breakthrough bleeding, and consider backup contraception only if prolonged oral antibiotic therapy causes vomiting or diarrhea.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
