Drug interactions
Dienogest / estradiol valerate + Moxifloxacin
Severity: Minor
Dienogest / estradiol valerate and Moxifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been hypothesized to reduce hormone exposure by altering gut flora. Data do not support a meaningful reduction with fluoroquinolones, so contraceptive failure is unlikely.
What this interaction means in plain words
Dienogest / estradiol valerate and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduced enterohepatic recycling of estrogen due to gut flora changes, not established for moxifloxacin.
What to do
No change in contraception is required. Counsel patients to report breakthrough bleeding or vomiting and diarrhea that could affect absorption.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Moxifloxacin?
MediHelp rates the interaction as minor. Dienogest / estradiol valerate and Moxifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been hypothesized to reduce hormone exposure by altering gut flora. Data do not support a meaningful reduction with fluoroquinolones, so contraceptive failure is unlikely.
How serious is the interaction between Dienogest / estradiol valerate and Moxifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No change in contraception is required. Counsel patients to report breakthrough bleeding or vomiting and diarrhea that could affect absorption.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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