Drug interactions
Dienogest / estradiol valerate + Voriconazole
Severity: Moderate
Dienogest / estradiol valerate and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise exposure to dienogest and estradiol, increasing hormone-related effects such as nausea, breast tenderness, headache and irregular bleeding.
What this interaction means in plain words
Dienogest / estradiol valerate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4 metabolism of dienogest and estradiol.
What to do
Monitor for estrogenic and progestogenic adverse effects and reassess therapy if they are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Dienogest / estradiol valerate with Voriconazole?
MediHelp rates the interaction as moderate. Dienogest / estradiol valerate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise exposure to dienogest and estradiol, increasing hormone-related effects such as nausea, breast tenderness, headache and irregular bleeding.
How serious is the interaction between Dienogest / estradiol valerate and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic and progestogenic adverse effects and reassess therapy if they are troublesome.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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