Drug interactions
Diethylpropion + Haloperidol
Severity: Moderate
Diethylpropion and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic anorectic with stimulant properties, while haloperidol is a dopamine antagonist. They may oppose each other's effects, and stimulants can aggravate psychotic symptoms. Clinical data are scarce.
What this interaction means in plain words
Diethylpropion and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition between dopamine blockade and sympathomimetic stimulation.
What to do
Avoid use of diethylpropion in patients with psychosis where possible; otherwise monitor mental state and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Frequently asked questions
Can I take Diethylpropion with Haloperidol?
MediHelp rates the interaction as moderate. Diethylpropion and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diethylpropion is a sympathomimetic anorectic with stimulant properties, while haloperidol is a dopamine antagonist. They may oppose each other's effects, and stimulants can aggravate psychotic symptoms. Clinical data are scarce.
How serious is the interaction between Diethylpropion and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use of diethylpropion in patients with psychosis where possible; otherwise monitor mental state and blood pressure.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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