Drug interactions
Diethylpropion + Meperidine
Severity: Minor
Diethylpropion and Meperidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diethylpropion is a sympathomimetic stimulant that does not reliably offset opioid sedation. The combination may cause unpredictable CNS effects and added cardiovascular stimulation. Clinical data on this pair are limited.
What this interaction means in plain words
Diethylpropion and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing CNS stimulant and opioid effects; no well-established interaction mechanism.
What to do
No specific change is needed. Monitor blood pressure, heart rate and respiratory status.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Diethylpropion with Meperidine?
MediHelp rates the interaction as minor. Diethylpropion and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diethylpropion is a sympathomimetic stimulant that does not reliably offset opioid sedation. The combination may cause unpredictable CNS effects and added cardiovascular stimulation. Clinical data on this pair are limited.
How serious is the interaction between Diethylpropion and Meperidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific change is needed. Monitor blood pressure, heart rate and respiratory status.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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