Drug interactions
Difelikefalin + Gabapentin
Severity: Moderate
Difelikefalin and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause dizziness and somnolence, and gabapentin is cleared renally and accumulates in dialysis patients, increasing sedation. Concurrent use may produce additive drowsiness and fall risk.
What this interaction means in plain words
Difelikefalin and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Gabapentin belongs to Central Nervous System.
Why it happens
Additive CNS depression through pharmacodynamic effects.
What to do
Monitor for somnolence, dizziness and falls, and ensure gabapentin is dosed for renal function. Reassess therapy if sedation is significant.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gabapentin
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Gabapentin?
MediHelp rates the interaction as moderate. Difelikefalin and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause dizziness and somnolence, and gabapentin is cleared renally and accumulates in dialysis patients, increasing sedation. Concurrent use may produce additive drowsiness and fall risk.
How serious is the interaction between Difelikefalin and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for somnolence, dizziness and falls, and ensure gabapentin is dosed for renal function. Reassess therapy if sedation is significant.
What other medicines interact with Gabapentin?
MediHelp also lists interactions of Gabapentin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Gabapentin page.
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