Drug interactions
Difelikefalin + Ketamine
Severity: Moderate
Difelikefalin and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin is a peripherally restricted kappa opioid agonist that can cause somnolence and dizziness. Ketamine may add to these CNS effects.
What this interaction means in plain words
Difelikefalin and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Ketamine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excess sedation and dizziness, and counsel on fall risk and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketamine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Ketamine?
MediHelp rates the interaction as moderate. Difelikefalin and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin is a peripherally restricted kappa opioid agonist that can cause somnolence and dizziness. Ketamine may add to these CNS effects.
How serious is the interaction between Difelikefalin and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and dizziness, and counsel on fall risk and driving.
What other medicines interact with Ketamine?
MediHelp also lists interactions of Ketamine with, for example, Benzhydrocodone / acetaminophen, Brexanolone, Buprenorphine buccal. The full list is on the Ketamine page.
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