Drug interactions
Difelikefalin + Meclizine
Severity: Moderate
Difelikefalin and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin can cause somnolence and dizziness, and meclizine is also sedating. Together they may increase drowsiness and the risk of falls, particularly in dialysis patients.
What this interaction means in plain words
Difelikefalin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Meclizine belongs to Respiratory.
Why it happens
Additive CNS depressant effects from kappa-opioid receptor agonism and H1-antihistamine activity.
What to do
Monitor for excess sedation, dizziness and falls. Reduce the meclizine dose or choose a non-sedating alternative if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Meclizine?
MediHelp rates the interaction as moderate. Difelikefalin and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin can cause somnolence and dizziness, and meclizine is also sedating. Together they may increase drowsiness and the risk of falls, particularly in dialysis patients.
How serious is the interaction between Difelikefalin and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, dizziness and falls. Reduce the meclizine dose or choose a non-sedating alternative if symptoms develop.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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