Drug interactions
Difelikefalin + Olanzapine
Severity: Moderate
Difelikefalin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness, which may add to olanzapine's sedative effects. This may increase the risk of falls in dialysis patients.
What this interaction means in plain words
Difelikefalin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difelikefalin belongs to Dermatology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Monitor for excessive drowsiness, dizziness and falls. Reduce doses if sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Difelikefalin
- Acetazolamide + Difelikefalin Moderate
- Alprazolam + Difelikefalin Moderate
- Amantadine + Difelikefalin Moderate
- Amitriptyline + Difelikefalin Moderate
- Amobarbital + Difelikefalin Moderate
- Asenapine + Difelikefalin Moderate
Frequently asked questions
Can I take Difelikefalin with Olanzapine?
MediHelp rates the interaction as moderate. Difelikefalin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difelikefalin, a kappa opioid agonist, can cause somnolence and dizziness, which may add to olanzapine's sedative effects. This may increase the risk of falls in dialysis patients.
How serious is the interaction between Difelikefalin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness, dizziness and falls. Reduce doses if sedation is troublesome.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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