Drug interactions
Difenoxin + Hydromorphone
Severity: Moderate
Difenoxin and Hydromorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal related to diphenoxylate that can cause CNS depression at high doses. With hydromorphone, additive sedation and respiratory depression may occur.
What this interaction means in plain words
Difenoxin and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
Why it happens
Additive opioid-mediated CNS depression.
What to do
Use at the lowest effective doses and monitor for sedation and respiratory depression; avoid exceeding recommended antidiarrheal doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Hydromorphone?
MediHelp rates the interaction as moderate. Difenoxin and Hydromorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal related to diphenoxylate that can cause CNS depression at high doses. With hydromorphone, additive sedation and respiratory depression may occur.
How serious is the interaction between Difenoxin and Hydromorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at the lowest effective doses and monitor for sedation and respiratory depression; avoid exceeding recommended antidiarrheal doses.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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