Drug interactions
Difenoxin + Nabilone
Severity: Moderate
Difenoxin and Nabilone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is the active metabolite of diphenoxylate, an opioid antidiarrheal that can cause drowsiness and, at higher doses, CNS depression. With nabilone, sedation and impaired coordination may be increased.
What this interaction means in plain words
Difenoxin and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Difenoxin belongs to Gastrointestinal Tract; Nabilone belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression from opioid and cannabinoid effects.
What to do
Keep difenoxin at the lowest effective dose and monitor for excessive sedation. Warn patients to avoid driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabilone
Other interactions of Difenoxin
Frequently asked questions
Can I take Difenoxin with Nabilone?
MediHelp rates the interaction as moderate. Difenoxin and Nabilone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is the active metabolite of diphenoxylate, an opioid antidiarrheal that can cause drowsiness and, at higher doses, CNS depression. With nabilone, sedation and impaired coordination may be increased.
How serious is the interaction between Difenoxin and Nabilone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep difenoxin at the lowest effective dose and monitor for excessive sedation. Warn patients to avoid driving and alcohol.
What other medicines interact with Nabilone?
MediHelp also lists interactions of Nabilone with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Nabilone page.
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