Drug interactions
Diflunisal + Drospirenone
Severity: Moderate
Diflunisal and Drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this effect. Hyperkalemia is more likely in patients with renal, hepatic or adrenal insufficiency.
What this interaction means in plain words
Diflunisal and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Drospirenone belongs to Endocrine.
Why it happens
Additive reduction in renal potassium excretion from drospirenone's aldosterone antagonism and NSAID-induced suppression of renin-aldosterone and renal prostaglandins.
What to do
Check serum potassium during the first treatment cycle if diflunisal is used long term with drospirenone; avoid in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Drospirenone
Frequently asked questions
Can I take Diflunisal with Drospirenone?
MediHelp rates the interaction as moderate. Diflunisal and Drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs may add to this effect. Hyperkalemia is more likely in patients with renal, hepatic or adrenal insufficiency.
How serious is the interaction between Diflunisal and Drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first treatment cycle if diflunisal is used long term with drospirenone; avoid in patients with renal impairment.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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