Drug interactions
Diflunisal + Epoprostenol
Severity: Moderate
Diflunisal and Epoprostenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epoprostenol inhibits platelet aggregation and diflunisal also impairs platelet function, so bleeding risk may be increased. Patients on continuous epoprostenol infusion are exposed for long periods.
What this interaction means in plain words
Diflunisal and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Epoprostenol belongs to Genitourinary.
Why it happens
Additive antiplatelet effects: prostacyclin analog activity combined with cyclooxygenase inhibition.
What to do
Monitor for signs of bleeding and bruising, and avoid unnecessary NSAID use in patients on epoprostenol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Epoprostenol
- Acetylsalicylic acid + Epoprostenol Moderate
- Aescin + Epoprostenol Moderate
- Aldesleukin + Epoprostenol Moderate
- Alteplase + Epoprostenol Moderate
- Amlodipine-benazepril + Epoprostenol Moderate
- Amlodipine-hydrochlorothiazide-valsartan + Epoprostenol Moderate
Frequently asked questions
Can I take Diflunisal with Epoprostenol?
MediHelp rates the interaction as moderate. Diflunisal and Epoprostenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epoprostenol inhibits platelet aggregation and diflunisal also impairs platelet function, so bleeding risk may be increased. Patients on continuous epoprostenol infusion are exposed for long periods.
How serious is the interaction between Diflunisal and Epoprostenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and bruising, and avoid unnecessary NSAID use in patients on epoprostenol.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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