Drug interactions
Diflunisal + Fludrocortisone
Severity: Moderate
Diflunisal and Fludrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone also causes fluid retention, which NSAIDs can worsen, affecting blood pressure and edema.
What this interaction means in plain words
Diflunisal and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Fludrocortisone belongs to Endocrine.
Why it happens
Additive gastric mucosal injury, plus combined sodium and water retention from mineralocorticoid action and reduced renal prostaglandins.
What to do
Monitor blood pressure, edema, potassium and for GI symptoms, and consider gastroprotection in at-risk patients. Use the shortest NSAID course possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Fludrocortisone
Frequently asked questions
Can I take Diflunisal with Fludrocortisone?
MediHelp rates the interaction as moderate. Diflunisal and Fludrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids with NSAIDs raise the risk of gastric ulceration and bleeding. Fludrocortisone also causes fluid retention, which NSAIDs can worsen, affecting blood pressure and edema.
How serious is the interaction between Diflunisal and Fludrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, potassium and for GI symptoms, and consider gastroprotection in at-risk patients. Use the shortest NSAID course possible.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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