Drug interactions
Diflunisal + Flurbiprofen
Severity: Moderate
Diflunisal and Flurbiprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Taking two NSAIDs together increases gastrointestinal, renal and cardiovascular toxicity without added efficacy. Bleeding and kidney injury are the main concerns.
What this interaction means in plain words
Diflunisal and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Flurbiprofen belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition affecting platelets, gastric mucosa and renal prostaglandins.
What to do
Avoid duplicate NSAID therapy and use one agent at the lowest effective dose. Monitor renal function and for GI bleeding if overlap occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Flurbiprofen
- Flurbiprofen + Ketorolac Contraindicated
- Flurbiprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Flurbiprofen Major
- Acemetacin + Flurbiprofen Major
- Acetylsalicylic acid + Flurbiprofen Major
- Alteplase + Flurbiprofen Major
Frequently asked questions
Can I take Diflunisal with Flurbiprofen?
MediHelp rates the interaction as moderate. Diflunisal and Flurbiprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Taking two NSAIDs together increases gastrointestinal, renal and cardiovascular toxicity without added efficacy. Bleeding and kidney injury are the main concerns.
How serious is the interaction between Diflunisal and Flurbiprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate NSAID therapy and use one agent at the lowest effective dose. Monitor renal function and for GI bleeding if overlap occurs.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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