Drug interactions
Diflunisal + Garlic
Severity: Minor
Diflunisal and Garlic: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Garlic supplements have antiplatelet activity, which may add to the platelet inhibition and gastrointestinal bleeding risk of diflunisal. Clinical evidence is limited and mostly based on case reports and theoretical grounds.
What this interaction means in plain words
Diflunisal and Garlic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Garlic belongs to Gastrointestinal Tract.
Why it happens
Additive antiplatelet effects; garlic constituents may inhibit platelet aggregation.
What to do
Ask patients about supplement use and advise avoiding concentrated garlic supplements while taking diflunisal long term. Watch for bruising or bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Garlic
- Garlic + Saquinavir Major
- Aceclofenac + Garlic Moderate
- Acemetacin + Garlic Moderate
- Aescin + Garlic Moderate
- Alteplase + Garlic Moderate
- Argatroban + Garlic Moderate
Frequently asked questions
Can I take Diflunisal with Garlic?
MediHelp rates the interaction as minor. Diflunisal and Garlic have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Garlic supplements have antiplatelet activity, which may add to the platelet inhibition and gastrointestinal bleeding risk of diflunisal. Clinical evidence is limited and mostly based on case reports and theoretical grounds.
How serious is the interaction between Diflunisal and Garlic?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about supplement use and advise avoiding concentrated garlic supplements while taking diflunisal long term. Watch for bruising or bleeding.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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