Drug interactions
Diflunisal + Gliclazide
Severity: Moderate
Diflunisal and Gliclazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylate-type NSAIDs such as diflunisal may enhance sulfonylurea effects and cause hypoglycemia. Salicylates also have intrinsic glucose-lowering activity at higher doses.
What this interaction means in plain words
Diflunisal and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Gliclazide belongs to Endocrine.
Why it happens
Displacement from plasma protein binding plus an intrinsic hypoglycemic effect of salicylates adds to sulfonylurea action.
What to do
Monitor blood glucose when diflunisal is started or stopped. Lower the gliclazide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gliclazide
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Gliclazide?
MediHelp rates the interaction as moderate. Diflunisal and Gliclazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylate-type NSAIDs such as diflunisal may enhance sulfonylurea effects and cause hypoglycemia. Salicylates also have intrinsic glucose-lowering activity at higher doses.
How serious is the interaction between Diflunisal and Gliclazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when diflunisal is started or stopped. Lower the gliclazide dose if hypoglycemia occurs.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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