Drug interactions
Diflunisal + Glipizide-metformin
Severity: Moderate
Diflunisal and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates such as diflunisal can potentiate the hypoglycemic effect of sulfonylureas. NSAID effects on renal function also raise metformin accumulation risk.
What this interaction means in plain words
Diflunisal and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Glipizide-metformin belongs to Endocrine.
Why it happens
Salicylates may displace sulfonylureas from protein binding and have intrinsic glucose-lowering effects; renal prostaglandin inhibition reduces clearance.
What to do
Monitor glucose and renal function when combined, and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Glipizide-metformin?
MediHelp rates the interaction as moderate. Diflunisal and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates such as diflunisal can potentiate the hypoglycemic effect of sulfonylureas. NSAID effects on renal function also raise metformin accumulation risk.
How serious is the interaction between Diflunisal and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function when combined, and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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