Drug interactions
Diflunisal + Glyburide-metformin
Severity: Moderate
Diflunisal and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal, an NSAID, may potentiate the hypoglycemic effect of glyburide. NSAID-related renal impairment can also increase metformin accumulation and the risk of lactic acidosis.
What this interaction means in plain words
Diflunisal and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Glyburide-metformin belongs to Endocrine.
Why it happens
Possible protein-binding displacement of glyburide and NSAID effects on renal function; the mechanism is not firmly established.
What to do
Monitor blood glucose and renal function, and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Glyburide-metformin?
MediHelp rates the interaction as moderate. Diflunisal and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal, an NSAID, may potentiate the hypoglycemic effect of glyburide. NSAID-related renal impairment can also increase metformin accumulation and the risk of lactic acidosis.
How serious is the interaction between Diflunisal and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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