Drug interactions
Diflunisal + Hyaluronidase
Severity: Minor
Diflunisal and Hyaluronidase: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High systemic doses of salicylates have been reported to make tissues partly resistant to hyaluronidase, so the spreading effect may be reduced. This is mostly relevant with large salicylate doses.
What this interaction means in plain words
Diflunisal and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Hyaluronidase belongs to Miscellaneous.
Why it happens
Salicylates are thought to inhibit hyaluronidase activity, though the exact mechanism is not firmly established.
What to do
Be aware that a larger hyaluronidase dose may be needed to achieve adequate dispersion in patients on high-dose salicylates.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Hyaluronidase
Frequently asked questions
Can I take Diflunisal with Hyaluronidase?
MediHelp rates the interaction as minor. Diflunisal and Hyaluronidase have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High systemic doses of salicylates have been reported to make tissues partly resistant to hyaluronidase, so the spreading effect may be reduced. This is mostly relevant with large salicylate doses.
How serious is the interaction between Diflunisal and Hyaluronidase?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware that a larger hyaluronidase dose may be needed to achieve adequate dispersion in patients on high-dose salicylates.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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