Drug interactions
Diflunisal + Hydrochlorothiazide-telmisartan
Severity: Moderate
Diflunisal and Hydrochlorothiazide-telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal can blunt antihypertensive effects of the ARB and thiazide and, in volume-depleted or elderly patients, contribute to acute kidney injury and hyperkalemia.
What this interaction means in plain words
Diflunisal and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Hydrochlorothiazide-telmisartan belongs to Cardiovascular.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, compounding ARB and diuretic effects on glomerular filtration.
What to do
Minimize NSAID dose and duration, maintain hydration, and monitor blood pressure, creatinine and potassium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-telmisartan
- Aliskiren + Hydrochlorothiazide-telmisartan Contraindicated
- Dofetilide + Hydrochlorothiazide-telmisartan Contraindicated
- Hydrochlorothiazide-telmisartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-telmisartan Major
- Amifostine + Hydrochlorothiazide-telmisartan Major
- Amiloride + Hydrochlorothiazide-telmisartan Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Hydrochlorothiazide-telmisartan?
MediHelp rates the interaction as moderate. Diflunisal and Hydrochlorothiazide-telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diflunisal can blunt antihypertensive effects of the ARB and thiazide and, in volume-depleted or elderly patients, contribute to acute kidney injury and hyperkalemia.
How serious is the interaction between Diflunisal and Hydrochlorothiazide-telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Minimize NSAID dose and duration, maintain hydration, and monitor blood pressure, creatinine and potassium.
What other medicines interact with Hydrochlorothiazide-telmisartan?
MediHelp also lists interactions of Hydrochlorothiazide-telmisartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-telmisartan page.
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