Drug interactions
Diflunisal + Ibrutinib
Severity: Major
Diflunisal and Ibrutinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibrutinib impairs platelet function and carries a bleeding risk, which may be compounded by the antiplatelet and gastrointestinal effects of diflunisal. Serious hemorrhage has been reported with ibrutinib alongside antithrombotic agents.
What this interaction means in plain words
Diflunisal and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Ibrutinib belongs to Oncology.
Why it happens
Additive impairment of platelet function (BTK inhibition plus cyclooxygenase inhibition).
What to do
Avoid NSAIDs where possible in patients on ibrutinib and use paracetamol instead. If needed, monitor closely for bleeding and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Ibrutinib
- Abciximab + Ibrutinib Major
- Acetylsalicylic acid + Ibrutinib Major
- Alteplase + Ibrutinib Major
- Amobarbital + Ibrutinib Major
- Apalutamide + Ibrutinib Major
- Apixaban + Ibrutinib Major
Frequently asked questions
Can I take Diflunisal with Ibrutinib?
MediHelp rates the interaction as major. Diflunisal and Ibrutinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ibrutinib impairs platelet function and carries a bleeding risk, which may be compounded by the antiplatelet and gastrointestinal effects of diflunisal. Serious hemorrhage has been reported with ibrutinib alongside antithrombotic agents.
How serious is the interaction between Diflunisal and Ibrutinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAIDs where possible in patients on ibrutinib and use paracetamol instead. If needed, monitor closely for bleeding and consider gastroprotection.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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