Drug interactions
Diflunisal + Insulin glargine-lixisenatide
Severity: Minor
Diflunisal and Insulin glargine-lixisenatide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
High doses of salicylates can lower blood glucose and may increase the glucose-lowering effect of insulin. Hypoglycemia is possible, particularly with large or sustained doses.
What this interaction means in plain words
Diflunisal and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Insulin glargine-lixisenatide belongs to Endocrine.
Why it happens
Salicylates may enhance insulin secretion and sensitivity and reduce hepatic glucose output, adding to insulin action.
What to do
Monitor blood glucose when starting or stopping diflunisal at regular analgesic doses and reduce the insulin dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine-lixisenatide
- Albiglutide + Insulin glargine-lixisenatide Major
- Chlorpropamide + Insulin glargine-lixisenatide Major
- Dulaglutide + Insulin glargine-lixisenatide Major
- Ethanol + Insulin glargine-lixisenatide Major
- Exenatide injectable + Insulin glargine-lixisenatide Major
- Glimepiride + Insulin glargine-lixisenatide Major
Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Diflunisal with Insulin glargine-lixisenatide?
MediHelp rates the interaction as minor. Diflunisal and Insulin glargine-lixisenatide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. High doses of salicylates can lower blood glucose and may increase the glucose-lowering effect of insulin. Hypoglycemia is possible, particularly with large or sustained doses.
How serious is the interaction between Diflunisal and Insulin glargine-lixisenatide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping diflunisal at regular analgesic doses and reduce the insulin dose if hypoglycemia occurs.
What other medicines interact with Insulin glargine-lixisenatide?
MediHelp also lists interactions of Insulin glargine-lixisenatide with, for example, Albiglutide, Chlorpropamide, Dulaglutide. The full list is on the Insulin glargine-lixisenatide page.
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