Drug interactions
Diflunisal + Ofloxacin
Severity: Moderate
Diflunisal and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may increase the central nervous system stimulating effects of fluoroquinolones and lower the seizure threshold. Seizures are uncommon but are more likely at high fluoroquinolone doses, in older patients, in renal impairment or with epilepsy.
What this interaction means in plain words
Diflunisal and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones antagonize GABA-A receptors and NSAIDs may potentiate this effect; the precise mechanism is not fully established.
What to do
Avoid the combination in patients with seizure disorders or other risk factors for seizures. Otherwise use the lowest effective ofloxacin dose and counsel patients to report tremor, confusion or seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Diflunisal with Ofloxacin?
MediHelp rates the interaction as moderate. Diflunisal and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may increase the central nervous system stimulating effects of fluoroquinolones and lower the seizure threshold. Seizures are uncommon but are more likely at high fluoroquinolone doses, in older patients, in renal impairment or with epilepsy.
How serious is the interaction between Diflunisal and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with seizure disorders or other risk factors for seizures. Otherwise use the lowest effective ofloxacin dose and counsel patients to report tremor, confusion or seizures.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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