Drug interactions
Diflunisal + Paroxetine
Severity: Moderate
Diflunisal and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs combined with NSAIDs substantially increase the risk of bleeding, especially from the upper gastrointestinal tract.
What this interaction means in plain words
Diflunisal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
SSRI-induced depletion of platelet serotonin impairs aggregation, adding to NSAID antiplatelet effects and gastric mucosal injury.
What to do
Monitor for gastrointestinal bleeding and consider a proton pump inhibitor for gastroprotection, particularly in older patients or those with prior ulcers. Use the lowest NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Diflunisal with Paroxetine?
MediHelp rates the interaction as moderate. Diflunisal and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs combined with NSAIDs substantially increase the risk of bleeding, especially from the upper gastrointestinal tract.
How serious is the interaction between Diflunisal and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal bleeding and consider a proton pump inhibitor for gastroprotection, particularly in older patients or those with prior ulcers. Use the lowest NSAID dose for the shortest time.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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