Drug interactions
Diflunisal + Propranolol
Severity: Moderate
Diflunisal and Propranolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular NSAID use may blunt the antihypertensive effect of propranolol, leading to poorer blood pressure control.
What this interaction means in plain words
Diflunisal and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Propranolol belongs to Cardiovascular.
Why it happens
NSAID inhibition of vasodilatory prostaglandins and fluid retention counteract beta-blocker blood pressure lowering.
What to do
Monitor blood pressure when the NSAID is started, changed or stopped, and adjust antihypertensive therapy if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Diflunisal with Propranolol?
MediHelp rates the interaction as moderate. Diflunisal and Propranolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular NSAID use may blunt the antihypertensive effect of propranolol, leading to poorer blood pressure control.
How serious is the interaction between Diflunisal and Propranolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when the NSAID is started, changed or stopped, and adjust antihypertensive therapy if needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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