Drug interactions
Diflunisal + Tafluprost
Severity: Minor
Diflunisal and Tafluprost: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reports of the effect of NSAIDs on intraocular pressure lowering by ophthalmic prostaglandin analogues are conflicting. Systemic NSAIDs may reduce the effect of tafluprost, though the clinical significance is uncertain.
What this interaction means in plain words
Diflunisal and Tafluprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Tafluprost belongs to Genitourinary.
Why it happens
NSAID inhibition of prostaglandin synthesis may alter prostaglandin-mediated aqueous outflow; the mechanism is not firmly established.
What to do
No empirical change is needed; check intraocular pressure at routine follow-up and reassess if control is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Tafluprost
- Bimatoprost + Tafluprost Moderate
- Latanoprost + Tafluprost Moderate
- Tafluprost + Travoprost Moderate
- Acetylsalicylic acid + Tafluprost Minor
- Celecoxib + Tafluprost Minor
- Diclofenac + Tafluprost Minor
Frequently asked questions
Can I take Diflunisal with Tafluprost?
MediHelp rates the interaction as minor. Diflunisal and Tafluprost have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reports of the effect of NSAIDs on intraocular pressure lowering by ophthalmic prostaglandin analogues are conflicting. Systemic NSAIDs may reduce the effect of tafluprost, though the clinical significance is uncertain.
How serious is the interaction between Diflunisal and Tafluprost?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical change is needed; check intraocular pressure at routine follow-up and reassess if control is lost.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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