Drug interactions
Latanoprost + Tafluprost
Severity: Moderate
Latanoprost and Tafluprost: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two ophthalmic prostaglandin analogues has not been shown to improve IOP control and may lessen the effect or paradoxically raise IOP. It also duplicates class-related ocular adverse effects such as hyperemia.
What this interaction means in plain words
Latanoprost and Tafluprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Latanoprost belongs to Miscellaneous; Tafluprost belongs to Genitourinary.
Why it happens
Duplicate FP-receptor agonist therapy; the paradoxical IOP rise is observed but its mechanism is not clearly established.
What to do
Use a single prostaglandin analogue and add an agent from another class if additional IOP lowering is needed. Monitor IOP if a patient has been using both.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Latanoprost
- Bimatoprost + Latanoprost Moderate
- Latanoprost + Latanoprostene bunod Moderate
- Latanoprost + Travoprost Moderate
- Aspirin rectal + Latanoprost Minor
- Aspirin + Latanoprost Minor
- Bromfenac + Latanoprost Minor
Other interactions of Tafluprost
- Bimatoprost + Tafluprost Moderate
- Tafluprost + Travoprost Moderate
- Acetylsalicylic acid + Tafluprost Minor
- Celecoxib + Tafluprost Minor
- Diclofenac + Tafluprost Minor
- Diflunisal + Tafluprost Minor
Frequently asked questions
Can I take Latanoprost with Tafluprost?
MediHelp rates the interaction as moderate. Latanoprost and Tafluprost can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two ophthalmic prostaglandin analogues has not been shown to improve IOP control and may lessen the effect or paradoxically raise IOP. It also duplicates class-related ocular adverse effects such as hyperemia.
How serious is the interaction between Latanoprost and Tafluprost?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a single prostaglandin analogue and add an agent from another class if additional IOP lowering is needed. Monitor IOP if a patient has been using both.
What other medicines interact with Latanoprost?
MediHelp also lists interactions of Latanoprost with, for example, Bimatoprost, Latanoprostene bunod, Travoprost. The full list is on the Latanoprost page.
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