Drug interactions
Diflunisal + Tenecteplase
Severity: Major
Diflunisal and Tenecteplase: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal inhibits platelet function and can injure the gastric mucosa, while tenecteplase causes fibrinolysis. The combination raises the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
What this interaction means in plain words
Diflunisal and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diflunisal belongs to Musculoskeletal; Tenecteplase belongs to Cardiovascular.
Why it happens
Additive impairment of hemostasis from NSAID platelet inhibition and thrombolytic fibrinolysis.
What to do
Avoid NSAID use around thrombolysis where possible. If both are given, monitor closely for bleeding and hemoglobin changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Tenecteplase
- Alteplase + Tenecteplase Contraindicated
- Acetylsalicylic acid + Tenecteplase Major
- Apixaban + Tenecteplase Major
- Argatroban + Tenecteplase Major
- Dabigatran etexilate + Tenecteplase Major
- Dalteparin + Tenecteplase Major
Frequently asked questions
Can I take Diflunisal with Tenecteplase?
MediHelp rates the interaction as major. Diflunisal and Tenecteplase can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diflunisal inhibits platelet function and can injure the gastric mucosa, while tenecteplase causes fibrinolysis. The combination raises the risk of serious bleeding, including gastrointestinal and intracranial hemorrhage.
How serious is the interaction between Diflunisal and Tenecteplase?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid NSAID use around thrombolysis where possible. If both are given, monitor closely for bleeding and hemoglobin changes.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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