Drug interactions
Diflunisal + Tolmetin
Severity: Moderate
Diflunisal and Tolmetin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAIDs provide no added benefit and increase the likelihood of gastrointestinal ulceration, bleeding and renal toxicity. Their effects on platelets are additive.
What this interaction means in plain words
Diflunisal and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Tolmetin belongs to Musculoskeletal.
Why it happens
Additive cyclooxygenase inhibition reducing gastroprotective prostaglandins and platelet aggregation.
What to do
Avoid duplicate NSAID therapy and use only one agent at the lowest effective dose. Monitor for GI bleeding and renal function if both are unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Diflunisal with Tolmetin?
MediHelp rates the interaction as moderate. Diflunisal and Tolmetin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAIDs provide no added benefit and increase the likelihood of gastrointestinal ulceration, bleeding and renal toxicity. Their effects on platelets are additive.
How serious is the interaction between Diflunisal and Tolmetin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate NSAID therapy and use only one agent at the lowest effective dose. Monitor for GI bleeding and renal function if both are unavoidable.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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