Drug interactions
Diflunisal + Valganciclovir
Severity: Minor
Diflunisal and Valganciclovir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diflunisal may compete with ganciclovir, the active form of valganciclovir, for renal tubular secretion. This could raise ganciclovir exposure and increase hematologic and other dose-related toxicity, particularly in renal impairment.
What this interaction means in plain words
Diflunisal and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Diflunisal belongs to Musculoskeletal; Valganciclovir belongs to Anti Virals.
Why it happens
Competition between the anionic NSAID and ganciclovir for renal tubular secretion transporters reduces renal clearance.
What to do
Monitor blood counts and renal function if the combination is needed and adjust valganciclovir to renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Valganciclovir
Frequently asked questions
Can I take Diflunisal with Valganciclovir?
MediHelp rates the interaction as minor. Diflunisal and Valganciclovir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Diflunisal may compete with ganciclovir, the active form of valganciclovir, for renal tubular secretion. This could raise ganciclovir exposure and increase hematologic and other dose-related toxicity, particularly in renal impairment.
How serious is the interaction between Diflunisal and Valganciclovir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and renal function if the combination is needed and adjust valganciclovir to renal function.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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