Drug interactions
Diflunisal + Valsartan
Severity: Moderate
Diflunisal and Valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive effect of valsartan. In elderly or volume-depleted patients, the combination can cause acute kidney injury and hyperkalemia.
What this interaction means in plain words
Diflunisal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diflunisal belongs to Musculoskeletal; Valsartan belongs to Cardiovascular.
Why it happens
NSAID inhibition of renal vasodilatory prostaglandins combined with ARB effects on efferent arteriolar tone impairs glomerular filtration and potassium excretion.
What to do
Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Other interactions of Valsartan
- Aliskiren + Valsartan Contraindicated
- Sparsentan + Valsartan Contraindicated
- Aldesleukin + Valsartan Major
- Amifostine + Valsartan Major
- Amiloride + Valsartan Major
- Amlodipine-benazepril + Valsartan Major
Frequently asked questions
Can I take Diflunisal with Valsartan?
MediHelp rates the interaction as moderate. Diflunisal and Valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive effect of valsartan. In elderly or volume-depleted patients, the combination can cause acute kidney injury and hyperkalemia.
How serious is the interaction between Diflunisal and Valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and monitor blood pressure, serum creatinine and potassium after starting or changing the NSAID. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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