Drug interactions
Dihydroergotamine + Eletriptan
Severity: Contraindicated
Dihydroergotamine and Eletriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.
What this interaction means in plain words
Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Eletriptan belongs to Central Nervous System.
Why it happens
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects; dihydroergotamine is also a CYP3A4 substrate.
What to do
Avoid together and separate by at least 24 hours. Use only one agent per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Eletriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Eletriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Eletriptan and dihydroergotamine both constrict blood vessels, and together they may produce prolonged vasospasm. Cardiac and cerebral ischemia are the concern.
How serious is the interaction between Dihydroergotamine and Eletriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid together and separate by at least 24 hours. Use only one agent per attack.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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