Drug interactions
Dihydroergotamine + Dronedarone
Severity: Contraindicated
Dihydroergotamine and Dronedarone: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronedarone inhibits CYP3A4 and can raise dihydroergotamine levels. Excess ergot exposure can cause severe vasospasm and peripheral or cerebral ischemia.
What this interaction means in plain words
Dihydroergotamine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Dronedarone belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 reduces dihydroergotamine clearance.
What to do
Avoid the combination; use a non-ergot migraine therapy such as a triptan if appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Dronedarone?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Dronedarone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronedarone inhibits CYP3A4 and can raise dihydroergotamine levels. Excess ergot exposure can cause severe vasospasm and peripheral or cerebral ischemia.
How serious is the interaction between Dihydroergotamine and Dronedarone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use a non-ergot migraine therapy such as a triptan if appropriate.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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