Drug interactions
Dihydroergotamine intranasal + Ergotamine
Severity: Contraindicated
Dihydroergotamine intranasal and Ergotamine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are ergot alkaloids with vasoconstrictive actions, and intranasal dihydroergotamine is systemically absorbed. Together they can cause additive vasospasm and prolonged ischemia, and labeling advises against use of ergot drugs within a day of each other.
What this interaction means in plain words
Dihydroergotamine intranasal and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction from ergot alkaloid agonism at serotonin and adrenergic receptors.
What to do
Do not use together or within 24 hours of each other. Choose a single ergot agent or a non-ergot alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine + Ergotamine Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Ergotamine?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Ergotamine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both are ergot alkaloids with vasoconstrictive actions, and intranasal dihydroergotamine is systemically absorbed. Together they can cause additive vasospasm and prolonged ischemia, and labeling advises against use of ergot drugs within a day of each other.
How serious is the interaction between Dihydroergotamine intranasal and Ergotamine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together or within 24 hours of each other. Choose a single ergot agent or a non-ergot alternative.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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