Drug interactions
Dihydroergotamine intranasal + Esmolol
Severity: Moderate
Dihydroergotamine intranasal and Esmolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may leave the vasoconstriction caused by dihydroergotamine unopposed, potentially worsening peripheral ischemia or vasospasm. The risk is greater with non-selective agents and is lower with short-acting esmolol.
What this interaction means in plain words
Dihydroergotamine intranasal and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Blockade of beta-2 mediated vasodilation increases net alpha-mediated vasoconstriction from dihydroergotamine.
What to do
Monitor for cold extremities, numbness or pain, and stop dihydroergotamine if ischemic symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Dihydroergotamine intranasal with Esmolol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Esmolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may leave the vasoconstriction caused by dihydroergotamine unopposed, potentially worsening peripheral ischemia or vasospasm. The risk is greater with non-selective agents and is lower with short-acting esmolol.
How serious is the interaction between Dihydroergotamine intranasal and Esmolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, numbness or pain, and stop dihydroergotamine if ischemic symptoms appear.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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