Drug interactions
Dihydroergotamine intranasal + Labetalol
Severity: Moderate
Dihydroergotamine intranasal and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, which may be amplified by beta blockade that removes beta-2 mediated vasodilation. This may worsen peripheral ischemia or vasospasm, especially with repeated dosing.
What this interaction means in plain words
Dihydroergotamine intranasal and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ergot-induced vasoconstriction combined with beta-blockade that reduces beta-2 mediated vasodilation.
What to do
Counsel patients to report cold, numb or discolored extremities or chest pain, and limit dihydroergotamine to labeled doses. Discontinue it if ischemic symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Dihydroergotamine intranasal with Labetalol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal dihydroergotamine is systemically absorbed and causes vasoconstriction, which may be amplified by beta blockade that removes beta-2 mediated vasodilation. This may worsen peripheral ischemia or vasospasm, especially with repeated dosing.
How serious is the interaction between Dihydroergotamine intranasal and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report cold, numb or discolored extremities or chest pain, and limit dihydroergotamine to labeled doses. Discontinue it if ischemic symptoms develop.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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