Drug interactions
Dihydroergotamine intranasal + Metoprolol
Severity: Moderate
Dihydroergotamine intranasal and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can impair peripheral vasodilation while dihydroergotamine constricts blood vessels. Intranasal dosing gives lower exposure than injection, but additive vasospasm remains possible.
What this interaction means in plain words
Dihydroergotamine intranasal and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasoconstriction from ergot alpha-agonist activity and loss of beta2-mediated vasodilation.
What to do
Monitor for cold, painful or pale extremities and numbness; stop dihydroergotamine if signs of ischemia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Dihydroergotamine intranasal with Metoprolol?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers can impair peripheral vasodilation while dihydroergotamine constricts blood vessels. Intranasal dosing gives lower exposure than injection, but additive vasospasm remains possible.
How serious is the interaction between Dihydroergotamine intranasal and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold, painful or pale extremities and numbness; stop dihydroergotamine if signs of ischemia appear.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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