Drug interactions
Dihydroergotamine intranasal + Nicotine
Severity: Moderate
Dihydroergotamine intranasal and Nicotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both nicotine and dihydroergotamine cause vasoconstriction, so combined use may add to peripheral or coronary vasospasm. Smoking is also a risk factor for ergot-related ischemia.
What this interaction means in plain words
Dihydroergotamine intranasal and Nicotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic vasoconstriction through nicotine sympathetic stimulation and ergot alpha-adrenergic and serotonergic agonism.
What to do
Advise patients to avoid smoking and nicotine products around dihydroergotamine dosing. Monitor for cold extremities, paresthesia or chest pain and stop dihydroergotamine if ischemic symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicotine
- Adenosine + Nicotine Moderate
- Bupropion + Nicotine Moderate
- Dihydroergotamine + Nicotine Moderate
- Esketamine intranasal + Nicotine Moderate
- Nicotine + Solriamfetol Moderate
- Cabotegravir + Nicotine Minor
Frequently asked questions
Can I take Dihydroergotamine intranasal with Nicotine?
MediHelp rates the interaction as moderate. Dihydroergotamine intranasal and Nicotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both nicotine and dihydroergotamine cause vasoconstriction, so combined use may add to peripheral or coronary vasospasm. Smoking is also a risk factor for ergot-related ischemia.
How serious is the interaction between Dihydroergotamine intranasal and Nicotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid smoking and nicotine products around dihydroergotamine dosing. Monitor for cold extremities, paresthesia or chest pain and stop dihydroergotamine if ischemic symptoms occur.
What other medicines interact with Nicotine?
MediHelp also lists interactions of Nicotine with, for example, Adenosine, Bupropion, Dihydroergotamine. The full list is on the Nicotine page.
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