Drug interactions
Esketamine intranasal + Nicotine
Severity: Moderate
Esketamine intranasal and Nicotine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can raise blood pressure and heart rate. Esketamine causes transient hypertension after dosing, and nicotine may add to this effect.
What this interaction means in plain words
Esketamine intranasal and Nicotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathomimetic cardiovascular effects.
What to do
Check blood pressure before dosing esketamine and monitor afterward. Avoid nicotine around sessions in patients with elevated baseline blood pressure or cardiovascular disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Esketamine intranasal and Nicotine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicotine
- Adenosine + Nicotine Moderate
- Bupropion + Nicotine Moderate
- Dihydroergotamine intranasal + Nicotine Moderate
- Dihydroergotamine + Nicotine Moderate
- Nicotine + Solriamfetol Moderate
- Cabotegravir + Nicotine Minor
Frequently asked questions
Can I take Esketamine intranasal with Nicotine?
MediHelp rates the interaction as moderate. Esketamine intranasal and Nicotine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can raise blood pressure and heart rate. Esketamine causes transient hypertension after dosing, and nicotine may add to this effect.
How serious is the interaction between Esketamine intranasal and Nicotine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure before dosing esketamine and monitor afterward. Avoid nicotine around sessions in patients with elevated baseline blood pressure or cardiovascular disease.
What other medicines interact with Nicotine?
MediHelp also lists interactions of Nicotine with, for example, Adenosine, Bupropion, Dihydroergotamine intranasal. The full list is on the Nicotine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
