Drug interactions
Cabotegravir + Nicotine
Severity: Minor
Cabotegravir and Nicotine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicotine is not a recognized strong UGT1A1 or UGT1A9 inducer, and no meaningful reduction in cabotegravir exposure is established. Smoking-related effects are expected to be small.
What this interaction means in plain words
Cabotegravir and Nicotine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cabotegravir belongs to Anti Virals; Nicotine belongs to Respiratory.
Why it happens
No established mechanism of clinically relevant UGT induction by nicotine.
What to do
No dose adjustment is needed; continue routine virologic monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cabotegravir and Nicotine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Nicotine
- Adenosine + Nicotine Moderate
- Bupropion + Nicotine Moderate
- Dihydroergotamine intranasal + Nicotine Moderate
- Dihydroergotamine + Nicotine Moderate
- Esketamine intranasal + Nicotine Moderate
- Nicotine + Solriamfetol Moderate
Other interactions of Cabotegravir
- Apalutamide + Cabotegravir Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Cabotegravir + Oxcarbazepine Contraindicated
- Cabotegravir + Phenobarbitone Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Cabotegravir + Rifabutin Contraindicated
Frequently asked questions
Can I take Cabotegravir with Nicotine?
MediHelp rates the interaction as minor. Cabotegravir and Nicotine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nicotine is not a recognized strong UGT1A1 or UGT1A9 inducer, and no meaningful reduction in cabotegravir exposure is established. Smoking-related effects are expected to be small.
How serious is the interaction between Cabotegravir and Nicotine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; continue routine virologic monitoring.
What other medicines interact with Nicotine?
MediHelp also lists interactions of Nicotine with, for example, Adenosine, Bupropion, Dihydroergotamine intranasal. The full list is on the Nicotine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
