Drug interactions
Dihydroergotamine intranasal + Rizatriptan
Severity: Contraindicated
Dihydroergotamine intranasal and Rizatriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemically absorbed intranasal dihydroergotamine adds vasoconstrictor effect to rizatriptan, risking prolonged vasospasm and ischemic events.
What this interaction means in plain words
Dihydroergotamine intranasal and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.
What to do
Do not combine; separate by at least 24 hours. Choose one therapy for each attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
- Frovatriptan + Rizatriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine intranasal with Rizatriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine intranasal and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Systemically absorbed intranasal dihydroergotamine adds vasoconstrictor effect to rizatriptan, risking prolonged vasospasm and ischemic events.
How serious is the interaction between Dihydroergotamine intranasal and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; separate by at least 24 hours. Choose one therapy for each attack.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine, Eletriptan. The full list is on the Rizatriptan page.
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