Drug interactions
Dihydroergotamine + Rizatriptan
Severity: Contraindicated
Dihydroergotamine and Rizatriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan and dihydroergotamine are both vasoconstrictors, and combined use may cause prolonged vasospasm. Risks include myocardial, cerebral and peripheral ischemia.
What this interaction means in plain words
Dihydroergotamine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dihydroergotamine belongs to Central Nervous System; Rizatriptan belongs to Central Nervous System.
Why it happens
Additive vasoconstriction via 5-HT1B/1D agonism and ergot vascular receptor effects.
What to do
Avoid concurrent use and leave at least 24 hours between doses. Use only one agent per attack.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergoloid mesylates + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
- Frovatriptan + Rizatriptan Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Rizatriptan?
MediHelp rates the interaction as contraindicated. Dihydroergotamine and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rizatriptan and dihydroergotamine are both vasoconstrictors, and combined use may cause prolonged vasospasm. Risks include myocardial, cerebral and peripheral ischemia.
How serious is the interaction between Dihydroergotamine and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and leave at least 24 hours between doses. Use only one agent per attack.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Eletriptan. The full list is on the Rizatriptan page.
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