Drug interactions
Ergoloid mesylates + Rizatriptan
Severity: Contraindicated
Ergoloid mesylates and Rizatriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rizatriptan constricts cranial and other vessels, and ergoloid has some ergot-derived receptor activity, so additive vasoconstriction is possible. The vasoconstrictor effect of ergoloid is weak, but the class warning still applies.
What this interaction means in plain words
Ergoloid mesylates and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Additive vasoconstriction through serotonin receptor agonism and ergot-derived receptor effects.
What to do
Avoid combining and separate by at least 24 hours. Review whether ergoloid therapy is needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Rizatriptan
- Almotriptan + Rizatriptan Contraindicated
- Dihydroergotamine intranasal + Rizatriptan Contraindicated
- Dihydroergotamine + Rizatriptan Contraindicated
- Eletriptan + Rizatriptan Contraindicated
- Ergotamine + Rizatriptan Contraindicated
- Frovatriptan + Rizatriptan Contraindicated
Frequently asked questions
Can I take Ergoloid mesylates with Rizatriptan?
MediHelp rates the interaction as contraindicated. Ergoloid mesylates and Rizatriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Rizatriptan constricts cranial and other vessels, and ergoloid has some ergot-derived receptor activity, so additive vasoconstriction is possible. The vasoconstrictor effect of ergoloid is weak, but the class warning still applies.
How serious is the interaction between Ergoloid mesylates and Rizatriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining and separate by at least 24 hours. Review whether ergoloid therapy is needed.
What other medicines interact with Rizatriptan?
MediHelp also lists interactions of Rizatriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Rizatriptan page.
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