Drug interactions
Diltiazem + Etravirine
Severity: Moderate
Diltiazem and Etravirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine is a CYP3A4 inducer and may lower diltiazem exposure, reducing its antihypertensive or rate-control effect. Diltiazem, a moderate CYP3A4 inhibitor, may raise etravirine levels, though this is usually of limited consequence.
What this interaction means in plain words
Diltiazem and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Diltiazem belongs to Cardiovascular; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces CYP3A4 and diltiazem inhibits CYP3A4, so each affects the other's metabolism.
What to do
Monitor blood pressure and heart rate and titrate diltiazem dose to clinical response when etravirine is started or stopped. No routine etravirine dose change is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diltiazem
- Diltiazem + Flibanserin Contraindicated
- Diltiazem + Ivabradine Contraindicated
- Diltiazem + Lomitapide Contraindicated
- Diltiazem + Lonafarnib Contraindicated
- Acebutolol + Diltiazem Major
- Alfentanil + Diltiazem Major
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Diltiazem with Etravirine?
MediHelp rates the interaction as moderate. Diltiazem and Etravirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Etravirine is a CYP3A4 inducer and may lower diltiazem exposure, reducing its antihypertensive or rate-control effect. Diltiazem, a moderate CYP3A4 inhibitor, may raise etravirine levels, though this is usually of limited consequence.
How serious is the interaction between Diltiazem and Etravirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate diltiazem dose to clinical response when etravirine is started or stopped. No routine etravirine dose change is needed.
What other medicines interact with Diltiazem?
MediHelp also lists interactions of Diltiazem with, for example, Flibanserin, Ivabradine, Lomitapide. The full list is on the Diltiazem page.
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